Tetralogy of Fallot and Other Congenital Heart Defects in Hey2 Mutant Mice

Tetralogy of Fallot and Other Congenital Heart Defects in Hey2 Mutant Mice

Congenital malformations of the heart and circulatory system are the most common type of human birth defect. Recent studies have implicated the Notch signaling pathway in human cardiac development by demonstrating abnormalities of the JAG1 gene as the basis for Alagille syndrome and some cases of isolated tetralogy of Fallot or pulmonic stenosis. How the Notch pathway acts in cardiac developmen...

CONGENITAL HEART DISEASE Ventricular Arrhythmias in Postoperative Tetralogy of Fallot

Ventricular arrhythmias in patients after total surgical repair of tetralogy of Fallot have been associated with late sudden death. In this large multicenter retrospective study of 359 patients with postoperative tetralogy of Fallot, spontaneous ventricular premature complexes (VPCs) on 24. hour ambulatory electrocardiographic monitoring and laboratory-induced ventricular tachycardia (VT) by el...

Tetralogy of Fallot The evolution of congenital heart surgery

Concordance of congenital heart defects in two pairs of monozygotic twins: pulmonary stenosis and tetralogy of Fallot.

Two pairs of twins with specific concordance in congenital heart lesions are presented. We reviewed all the monozygotic twins with specific concordance in congenital heart lesions in the last 18 years. Two pairs were found. First, a pair of 13 years-old monozygotic female twins; a severe infundibular and pulmonary valve stenosis was discovered in both girls. In the second pair of twins (8 years...

Studies of blood volume in the tetralogy of Fallot and in other types of congenital heart disease.

The recent introduction by Blalock (1) of an operative procedure for the successful treatment of the tetralogy of Fallot has focused considerable attention on the various manifestations of this condition. It has also indicated the need of more information to aid in the diagnosis and prognosis, as well as in the preoperative and postoperative treatment of the patients with this disease. The pres...